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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

Fig. 4

Molecular and cellular characteristics of the cerebral occluded lesions in parietal cortex in 18 months eNOS+/- mice: partial eNOS deficiency causes cerebral thrombosis. a Representative images of H & E Staining (6 μm coronal sections). b GFAP/Iba-1 immunohistochemistry on 12 months eNOS brains. Scale bars: 20 μm. c Representative images of fibrinogen/fibrin (red) and/or CD31 (green) immunohistochemistry in 18-month-old eNOS+/- mice. White arrows indicate a string of fibrinogen/fibrin-positive signals lining with CD31-positive vessels (upper) and individual fibrinogen clots inside the arterioles (lower, insets). Scale bars: Upper panels: 50 μm; Lower panel: 500 μm (insets, 50 μm)

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