Fig. 5

Partial eNOS deficiency promotes CAA. a Representative images of anti-Aβ (4G8, green) and GLUT1 (green) immunohistochemistry on cerebral cortex (100 X). b, c Representative images of anti-Aβ (4G8, red) and CD31 (green) immunohistochemistry on cerebral cortex (Scale bars: 100 μm) (B) and on hippocampal fissure (C, Scale bars: 50 μm). d Quantification of Aβ-positive arterioles in hippocampal fissure. *P = 0.01; **P < 0.001. n = 5–6 mice each genotype. e Representative images of double immunohistochemistry in hippocampal fissure. Scale bars, 50 μm. E) Representative images of Thioflavine S images taken from cortex. f Quantification of forebrain soluble Aβ40 levels by ELISA (Life Technologies, CA, Cat^#KMB3481). n = 5 each genotype