Fig. 7From: Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment a Cognitive functions in heterozygous eNOS knockout (eNOS+/-) mice. Spatial learning and memory evaluated by water maze tests reveals no significant differences between young (6-month-old) eNOS+/- mice and their littermate wild-type (eNOS+/+) mice (n = 10 each genotype), but severe impairment in aged eNOS+/- mice when compared to eNOS+/+ mice (n = 18 each). Data are presented as means ± SEM. **P <0.005 when eNOS+/- 18months group was compared to that of the littermate eNOS+/+ mice. b Representative images of GFAP and Iba-1 double immunohistochemistry. White arrowheads indicate activated microglias. Scale bars: 50 μm form the left panels and 25 μm for the right panels. c Schematic summary of the relative locations of the identified occluded lesions (black) and CAA (red) in old eNOS+/- miceBack to article page