Fig. 6From: Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulatorPAA-extended C5 alkylene tether grafting analogs. a PAA compounds combined with the COOH-tether were synthesized. b-c The treatments of the grafted compounds did not alter Aβ40 and Aβ42 levels significantly at 300nM or 3 μM concentrationsBack to article page