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Table 1 CA analogs EC50 for lowering Aβ42

From: Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

R1

Cmpd#

Aβ42 EC50 (nM)

5

1780

6

1960

7

110

8

148

2a

250

2b

501

9

2193

10

391

11

513

  1. EC50=half maximal effective concentration