Fig. 6
From: Mutations in LRRK2 potentiate age-related impairment of autophagic flux
Survival of dopaminergic neurons in C. elegans lines expressing α-synuclein and LRRK2. The expression profile of a dat-1::GFP reporter was followed to monitor the fluorescence intensity of CEP neurons over much of the lifespan in C. elegans lines expressing α-synuclein ± LRRK2 (WT, G2019S or Δlrk-1). Inset: Photos from representative adult day 2 and adult day 7 nematodes expressing dat-1::GFP/dat-1::α-Synuclein/snb::G2019S LRRK2 showing the fluorescence of GFP in the CEP neurons and nerve ring. N = 30 animals/condition, **P < 0.001, *P < 0.01 and #P < 0.05 compared to dat-1::GFP. The G2019S and WT LRRK2/α-synuclein lines also differed from the α-synuclein line at days 16–20 at P < 0.001