Fig. 5
From: Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS
Microglial Iba1 and Brca1 expression within adjacent human control and ALS spinal cord. Brightfield micrographs indicating Iba1 and Brca1 expression within adjacent sections of control (a–d) and ALS (e–h) spinal cords. Both Ibal and Brca1-labelled microglia displayed typical ramified morphology in the control spinal cords with small cell bodies and large and thin processes (c & d). Microglial morphology displayed similar features following Iba1 (a & c) and Brca1 (b & d) immuno staining. In ALS spinal cords, Ibal and Brca1-labelled microglia displayed both ramified and activated microglia with enlarged cell bodies and short and thick processes (g & h). Microglial morphology were similar using Iba1 (e & g) or Brca1 (f & h) immuno staining. Scale bars (a–h): 50 μm