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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

Fig. 3

Quantifications of CLU-EGFP intensity in ER and Golgi of HeLa cells expressing CLU mutations. a For Golgi the ratio of the mean CLU-EGFP intensity inside versus outside the Golgi region was determined after excluding cells with low EGFP signal outside Golgi. b For ER, the Pearson’s correlation coefficient between the fluorescence channels of CLU-EGFP and PDI is represented. Measurements were performed on individual cells with ImageJ. Data are represented as median values, with lower and upper quartiles and the value ranges (whiskers) with a minimum of 20 cells per CLU variant. (*p < 0.05; **p < 0.01 after Bonferroni correction)

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