Fig. 4

Splicing patterns of human Tau transcripts. a Classical splicing pattern described in the literature. The insertion of exons 4A and 6 rarely occurs in the brain (shaded in pale orange) and varies according to which 3’ splice site is used. E8 insertion (shaded in dark orange) has not been reported in humans but has been described in different animal models and in the human Ensembl database. b Hypothetical splicing according to the Ensembl database. The MAPT numbers correspond to those in the Ensembl database. White, non-coding regions; gray, constitutive coding exons. Yellow, orange, pink, green, purple and blue represent the alternative exons 2, 3, 4A, 6, 8 and 10, respectively