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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Fig. 4

AAV expression of UBQLN2 WT and mutants is specific to neurons. Images are merged photos of representative cortical areas from 6 month mice stained with immunofluorescence for NeuN/GFAP/Iba-1 (red), ubiquilin-2 (green), and DAPI (blue). The top 2 rows show colocalization of ubiquilin-2 accumulations with NeuN-positive neurons. Row 2 includes high-power confocal images that demonstrate differences in the distribution of ubiquilin-2-containing inclusions in NeuN labeled neurons; large inclusions are seen for all mutant forms in contrast to WT ubiquilin-2. Glial markers GFAP (row 3) and Iba-1 (row 4) rarely colocalize with ubiquilin-2. (Scale bar = 50 μm unless otherwise noted)

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Molecular Neurodegeneration

ISSN: 1750-1326