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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Fig. 6

TDP43 colocalizes with ubiquilin-2 in mice expressing mutant UBQLN2 (P506T). a) Low power merged immunofluorescent images of CA3 hippocampus from mice injected with rAAV expressing WT or P506T mutant ubiquilin-2 and aged 6 months. TDP43 (red) colocalizes (arrowheads) with several ubiquilin-2-positive (green) inclusions in mutant P506T expressing mice. (bar = 25 μm) b) Higher power photomicrographs show cytoplasmic TDP43 puncta stained with the phospho-TDP43 antibody (403–404) within a large cytoplasmic ubiquilin-2-positive inclusion. (bar = 25 μm) c) Confocal Z-slice section analysis of ubiquilin-2 inclusions (green) similarly demonstrates colocalization of phosphorylated TDP43 (red) in brain tissue from mice expressing mutant UBQLN2 (P506T)

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