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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 1

Behavioral assessment of sensorimotor function and activity in 12- and 15-month-old mice treated either with melatonin (MEL) or vehicle (EtOH). The Rota-rod revealed no significant difference at any age in the length of time balance was maintained on a rotating horizontal rod that accelerated from 4 to 40 rpm. A test of visual and motor skills in a water maze Platform Recognition test revealed no significant differences. Animals in both groups were able to see, swim to, and climb onto the platform. Locomotor activity was assessed with an Open Field test. No significant differences were found in control (NonAD) or 2xAD mice either with melatonin receptors (MTNR+) or without melatonin receptors (MTNR-). All tests were evaluated with 2-way ANOVA; 12-month n = 11–14; 15-month n = 4–7; error bars represent SEM; p > 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326