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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 2

Determination of anxiety levels by time in spent in the open arms of the Elevated Plus Maze. No significant differences were seen in either the 12-month-old or in the 15-month-old NonAD control or 2xAD mice, irrespective of the whether they possessed melatonin receptors (MTNR+) or lacked them (MTNR-). Evaluated with 2-way ANOVA; 12-month n = 10-13; 15-month n = 4–7; error bars represent SEM; p > 0.05

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