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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 3

Measurement of non-spatial memory in 15-month-old mice with the novel object recognition test. This test evaluates the difference in time spent investigating a familiar versus foreign object. The vehicle-treated 2xAD mice (clear yellow and white bars) showed significantly poorer performance when compared to the NonAD/MTNR+ control mice with or without MEL. This was alleviated in the 2xAD mice that had received melatonin (MEL; striped bars), irrespective of the presence (MTNR+) or absence (MTNR-) of melatonin receptors. Evaluated with 2-way ANOVA; n = 4–7; error bars represent SEM; p < 0.05

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Molecular Neurodegeneration

ISSN: 1750-1326