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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 4

Spatial learning and memory in AD mice as determined with the Barnes Maze. a Latency to find the escape hole decreased over 8 days of testing in 15-month old 2xAD/MTNR+ mice that received MEL, but not in MEL-treated 2xAD/MTNR- mice. b Comparison of the average latency to escape on initial testing (days 1–4) for 12-month-old 2xAD mice as compared to the same mice at 15 months of age during final testing (days 5–8). Only the 2xAD/MTNR+ that received MEL exhibited significantly improved performance. Evaluated with 2-way RM ANOVA; n = 4–7; error bars represent SEM; p < 0.05

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