Fig. 6From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 miceA Kaplan-Meier survival curve for the 2xAD mice over the course of the study. The mice with melatonin receptors (MTNR+) suffered no losses (n = 35), while the mice lacking melatonin receptors (MTNR-) had increasing mortality beginning at 70 days (from n = 62 only 41 survived). MEL or vehicle treatment had no effect on survivalBack to article page