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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 7

Immunohistochemical detection of amyloid plaques in the hippocampus of 15-month-old 2xAD mice treated with either MEL (c, d) or vehicle (a, b). NonAD mice did not develop plaques (E). Quantitative analysis of plaque load with ImageJ revealed significant MEL effects in both MTNR+ (p < 0.0001) and MTNR- (p = 0.0034) 2xAD hippocampi (f). Similar MEL effects were also seen in the frontal cortex (g) in both the 2xAD/MTNR+ mice (p = 0.0001) and in the 2xAD/MTNR- mice (p = 0.0333). Evaluated with 2-way ANOVA; n = 3–4; error bars represent SEM

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