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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice

Fig. 8

ELISA measurement of plasma Aβ1–40 and Aβ1–42 levels in 9-month-old and 14-month-old 2xAD mice. In all cases, MEL tended to lower amyloid peptide levels. A significant effect of MEL was seen at 14 months for Aβ1–42 levels in both MTNR+ mice (p = 0.0043) and in MTNR- mice (p = 0.011). Evaluated with 2-way ANOVA; n = 3–5; error bars represent SEM

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Molecular Neurodegeneration

ISSN: 1750-1326