Fig. 2
From: Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain
Unchanged levels of p-tau in Akt single isoform KO mice. a Nissl staining for the brain of Akt1 −/− mice. Normal brain structure was observed. b Western analyses on p-tau levels using cortical samples of Akt1 −/− mice. There was no significant difference on relative levels of p-tauThr205, p-tauThr231 and p-tauSer396 in Akt1 −/− mice. c Nissl staining for the brain of Akt2 −/− mice. No abnormal brain structure was detected. d Western analyses on p-tau levels using cortical samples of Akt2 −/− mice revealed no significant difference. e Nissl staining for the brain of Akt3 −/− mice. There was a smaller brain in Akt3 −/− mice than in WT animals. f Western analyses on p-tau levels showed no significant difference in Akt3 −/− mice (NS = not significant)