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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion

Fig. 1

Nav1.1 and Nav1.2 trafficking were disturbed in hippocampi and cortices after chronic brain hypoperfusion (CBH). a, western-blot analysis of the surface protein levels of Nav1.1 and Nav1.2 in sham and 2VO rats, upper: representative immunoblots of Nav1.1 and Nav1.2; lower: the quantitative analysis data of the immunoblots. The optical density was evaluated for each band and values for 2VO rat tissue were normalized to sham group after correction for protein loading with TfR,**P < 0.01 vs sham, mean ± s.e.m, n = 6. b, western-blot analysis of the total protein levels of Nav1.1 and Nav1.2 in sham and 2VO rats, upper: representative immunoblots of Nav1.1, Nav1.2; lower: the quantitative analysis data of the immunoblots. The optical density was evaluated for each band and values for 2VO rat tissue were normalized to sham group after correction for protein loading with β-actin. **P < 0.01 vs sham, mean ± s.e.m, n = 6

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Molecular Neurodegeneration

ISSN: 1750-1326