Skip to main content
Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion

Fig. 6

MiR-9 produces the disturbance of trafficking, cellular distribution of Nav1.1 and Nav1.2 in rats. a, Detection of miR-9 in hippocampi and cortices tissues after stereotaxic injection 8 weeks using qRT-PCR. Rats were transfected with lenti-pre- miR-9, lenti-pre-miR-9 + lenti-pre-AMO-miR-9, or NC. Data was shown by mean ± s.e.m from 6 rats for each group. *P < 0.05 vs NC; # P < 0.05 vs lenti-pre- miR-9. b, Navβ2 protein expressions in hippocampi and cortices tissues after treatment by lenti-pre-miR-9, lenti-pre-miR-9 + lenti-pre-AMO-miR-9, or NC for 8 weeks. c-f, Nav1.1 (C-D), Nav1.2 (E-F) total and surface protein expressions in hippocampi and cortices tissues after treatment by lenti-pre-miR-9, lenti-pre-miR-9 + lenti-pre-AMO-miR-9, or NC for 8 weeks. *P < 0.05,**P < 0.01 vs NC; # P < 0.05, ## P < 0.01 vs lenti-pre- miR-9, mean ± s.e.m, n = 6

Back to article page