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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion

Fig. 7

AMO-miR-9 prevented the disturbed trafficking of Nav1.1/Nav1.2 induced by 2VO. a, Detection of miR-9 in hippocampi and cortices tissues after stereotaxic injection 8 weeks using qRT-PCR. 2VO rats were transfected with lenti-pre-AMO-miR-9, or NC. Data was shown by mean ± s.e.m from 6 rats for each group. *P < 0.05vs sham; # P < 0.05 vs 2VO. b, Navβ2 protein expressions in hippocampi and cortices tissues in 2VO rats with or without lenti-pre-AMO-miR-9 treatment, or NC for 8 weeks. c-f, Nav1.1 (C-D), Nav1.2 (E-F) total and surface protein expressions in 2VO rats with or without lenti-pre-AMO-miR-9 treatment, or NC for 8 weeks. *P < 0.05,**P < 0.01 vs sham; # P < 0.05, ## P < 0.01 vs 2VO, mean ± s.e.m, n = 6

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Molecular Neurodegeneration

ISSN: 1750-1326