Fig. 2

Pharmacokinetics and pharmacodynamics of NB-360 in rats after oral dosing. The significance of differences in effect sizes (analyzed as % of vehicle) produced by the doses within each timepoint was tested. a-c: 3 μmol/kg (squares), 10 μmol/kg (circles), and 30 μmol/kg (triangles). Mean values ± SD are shown, n = 5. a NB-360 exposure in blood and brain. b Aβ40 in forebrain, *p < 0.05 3 vs 10 μmol/kg, $ p < 0.05 3 vs 30 μmol/kg, # p < 0.01 3 vs 30 μmol/kg c: Aβ40 in CSF, ***p < 0.001 3 vs 10 μmol/kg, $ p < 0.05, $$ p < 0.01, $$$ p < 0.001 3 vs 30 μmol/kg, # p < 0.05 and ### p < 0.001 10 vs 30 μmol/kg, d: Dose-response in brain based on 4 h data