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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

Fig. 6

Effect of NB-360 treatment on the number of GFAP-positive astrocytes and Iba-1 positive microglia cell clusters illustrating accumulation of astrocytes and microglia in the vicinity of amyloid plaques. a Triple staining of cerebral cortex for aggregated Aβ (blue), GFAP (red) and Iba-1 (green). b Quantitative analysis of GFAP+ and Iba-1+ clusters in cortex. Shown are mean ± SEM, **p < 0.01 (Dunnett’s multiple comparisons test) c: correlation of total Aβ stained area in cortex with GFAP+ clusters. d Correlation of total stained Aβ area in cortex with Iba-1+ clusters. Solid line represents the linear fit, and dashed lines the 95 % confidence interval

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