Table 1 Physico-chemical and transport properties of NB-360
Molecular weight | 449.5 |
logP (octanol/water) | 3.7 |
Dissociation constant (pKa) | 7.1 |
Passive membrane permeability (logPe pH 6.8) | -3.6 cm s-1 |
MDR1- MDCK flux apical-basolateral (A-B) | 14.1• 10-6 cm s-1 |
MDR1- MDCK flux basolateral-apical (B-A) | 26.3• 10-6 cm s-1 |
MDR1- MDCK efflux ratio (B-A/A-B) | 1.9 |
Plasma protein binding (rat) | 93.8 % |
Plasma protein binding (dog) | >99 % |
Non-specific brain homogenate binding (rat) | 97.7 % |