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Table 2 NB-360 concentrations in rat blood and brain, after a 30 μmol/kg oral dose

From: A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

 

Blood

Brain

Cmax (1 h, μM)

1.62

4.01

AUC 0-24 h (μM•h)

10.2

23.6

unbound AUC 0-24 h (μM•h)

0.63

0.54