Table 4 Formic-acid extracted Aβ peptides in forebrain homogenates (pmol/g forebrain)
Aβ species | Mean ± SEM | NB-360 group, change vs baseline | NB-360 group, change vs vehicle | ||
|---|---|---|---|---|---|
Baseline | Vehicle | NB-360 | |||
N | 13 | 17 | 14 | ||
1-38 | 115.9 ± 38.0 | 240.3 ± 53.1 | 77.0 ± 24.9 | -33.5 % p = 0.39 | -68.0 % p = 0.015 |
1-40 | 235.1 ± 37.4 | 556.1 ± 92.0 | 197.3 ± 43.4 | -16.1 % p = 0.52 | -64.5 % p = 0.003 |
1-42 | 139.8 ± 25.1 | 347.6 ± 53.6 | 106.6 ± 20.9 | - 23.7 % p = 0.41 | -69.3 % p = 0.0006 |