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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

Fig. 2

Progressive phenotypes of transgenic TDP-43 pigs. a Body weight reduction in different transgenic TDP-43 pigs at different ages. b Body weight (mean ± SE) of non-transgenic and transgenic TDP-43 pigs at 3, 4, 9 and 10 months of age (n = 5 for non-TG (Control) and n = 5 for TDP-43 transgenic pigs (TG)). * p < 0.05; ** p < 0.01. c Western blots analysis of ear tissues showing the expression of transgenic TDP-43 pigs that were monitored for their body weights. d Survival plot showing that expression of mutant TDP-43 caused early death of TDP-43 transgenic (TG) pigs (n = 12 for non-TG (Control) and n = 27 for TG). e Photographs of representative non-transgenic (Control) and TDP-43 transgenic pig (TG-16, 18, 24) at 9 months of age. f Summary of some transgenic pigs for their genotypes and phenotypes. C: Genotype is non-transgenic with the endogenous copies of pig TDP-43

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