Skip to main content
Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

Fig. 4

Expression of mutant TDP-43 in transgenic pigs causes neurodegeneration and muscle atrophy. a CHAT- and NeuN-immunostaining of the pig spinal cord showing a reduced number of motor neurons in TDP-43 transgenic pigs (TG-16 and 18) at 10–11 months of age. Control: non-transgenic. Scale bars: 200 μm. b Quantitative analysis of the number (mean ± SE) of NeuN- and CHAT-positive neurons per ventral horn in the spinal cord sections. Five-eight images obtained with 20x N.A. 0.8 objective per section and 5 sections per group were analyzed. C: non-transgenic. c Skeletal muscle atrophy in TDP-43(M337V) transgenic pigs. Haematoxylin and eosin-stained cross-sections gastrocnemius muscles from 10-month-old non-transgenic (Control) and TDP-43(M337V) transgenic (TG-16) pigs. Scale bar: 50 μm. d More than 3 random fields (corresponding to 200–300 cross-sectioned fibers) were examined for quantification of muscle fibers of different sizes

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326