Fig. 1

Genetic Pedigrees. Simplified pedigree structures in which arrows are used to indicate the proband, circles indicate females, squares indicate males and diamonds indicate individuals of indeterminate or undisclosed gender, a G51D case one (patient II,1). The father of case one was diagnosed with PD (grey), his mother was unaffected (white). His sister carries the G51D mutation and developed PD symptoms at 40 years of age. b G51D cases two (patient III, 2) and three (patient IV, 2), Case two is the parent of case three. A sibling and two members of the previous generation of case two were diagnosed with PD without dementia (grey). c SNCA duplication case (patient III, 3), The father of the duplication case, paternal grandmother and two paternal great-aunts suffered from PD without documented dementia. Her paternal cousin was diagnosed with possible FTDP-17. The H50Q case did not have a family history of Parkinsonism