Fig. 1
From: Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death
Activation of caspase-7 in mouse retina by ON crush. aRepresentative western blot images of pro- (uncleaved) and activated (cleaved) caspase-7 in protein extracts from ON crush (12 h, 1 d, 3 d, and 7 d post-injury) and control uninjured retinas of WT mice. b Densitometry analysis of western blot images showing a significant increase of active caspase-7 levels in ON crush eyes at the indicated time points when compared to uninjured eyes (Right graph). The values were normalized to β-actin and presented as the mean ± SD (n = 4). **: p < 0.01, ***: p < 0.001 by unpaired, two-tailed Student’s t-test