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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death

Fig. 2

Activation of caspase-7 in RGCs by ON crush. Representative images of retinal cryosections from an uninjured control eye of WT mouse (upper panel) and an eye 3 d after ON crush (lower panel), immunolabeled with cleaved caspase-7 antibody (green fluorescence), RBPMS antibody (red), and DAPI (blue). ON crush increased cleaved caspase-7 levels mainly in the ganglion cell layer, most of which co-localized with the RGC-specific marker RBPMS (arrows). Scale bars = 50 μm. GCL: ganglion cell layer, IPL: Inner plexiform layer, INL: inner nuclear layer

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