Skip to main content
Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Fig. 4

N279K fibroblasts do not display alterations in cellular stress or markers of vesicle trafficking. a LDH secretion was measured in control and N279K fibroblasts. The quantification was normalized to Bradford protein levels of cell lysate. b Caspase 3/7 activity was measured in control and N279K fibroblasts. The quantification was normalized to Bradford protein levels of cell lysate. c Immunostaining of control and N279K fibroblasts, demonstrating EEA1, Flotillin-1 and LAMP-1 positive punctates. d-h Expression levels of EEA1 e, CHMP2B f, Flotillin-1 g and LAMP-1 h in control and N279K fibroblasts were analyzed by Western blot. Data are mean ± SEM from three independent experiments. N.S., Not Significant

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326