Fig. 5

Histopathologic findings and Western blot analysis of cortex in autopsy-confirmed PPND/FTDP-17 patients with N279K tau mutant. a Neuronal loss and superficial microvacuolation demonstrated by H & E staining in the frontal and b temporal cortex, but c occipital cortex is relatively spared in PPND/FTDP-17 patients. Scale bar, 100 μm. d Phospho-tau-positive pre-tangles, threads, and coiled bodies in frontal cortex and e temporal cortex but, f only rare threads and glia are found in occipital cortex of PPND/FTDP-17 patients. Scale bar, 25 μm. g Ballooned neurons detected by αB-crystallin staining are found in the frontal and h temporal cortex, but i only rare αB-crystallin-positive glia are found in occipital cortex from PPND/FTDP-17 patients. Scale bar, 25 μm. j-l Western blot analysis of Flotillin-1 levels in the frontal j, temporal k and occipital l cortex from control non-demented controls (n = 4) and PPND/FTDP-17 patients (n = 4). Data are mean ± SEM. *p < 0.05