Fig. 8

Treatment with LV-NR-R80Q-apoB improves the behavioral deficits in MBP-α-syn tg mice. Non-tg mice or MBP-α-syn tg mice treated with LV-Control or LV-NR-R80Q-apoB were tested in the open field test for 4 successive days or for a fixed period to ascertain the functional effects of LV-NR-R80Q-apoB treatment. a Total activity after consecutive days was performed, this is a test of habituation to a novel environment and of memory acquisition. b Retention score analysis representing the ratio between trials 3 and 4. c Total spontaneous activity after 10 min in the open field test. d Total activity in the center of the cage, no differences were noted among the 4 groups. n = 10 mice per group 9–10 m/o at the end of the treatment. Scale bar = 10 μm. * indicates statistical significance (p < 0.05, one way ANOVA, poshoc Dunnett’s) compared to non-tg mice. # indicates statistical significance (p < 0.05, one way ANOVA, post hoc Tukey-Kramer) compared to LV-Control treated MBP-α-syn tg mice