Table 1 Open field performance for L + D (a), V + D (b), L + CV (c) and V + CV (d) rats. Hemi-lesioned rats (L + D and L + CV) were severely impaired in all principal motor behaviours and in aspects of complex behaviour, when comparing baseline performance with that at -CNO. When L + D rats were reassessed during + CNO, performance values indicated complete recovery

Principally motor behavior

Ambulation count (N)

8.92 (±0.54)

5.25 (±0.43)

12.67 (±0.85)

Average speed (m/s)

0.47 (±0.02)

0.29 (±0.02)

0.48 (±0.02)

Maximum speed (m/s)

0.74 (±0.02)

0.48 (±0.02)

0.75 (±0.02)

Time spent mobile (s)

212.13 (±5.16)

193.28 (±2.68)

211.88 (±3.30)

Distance covered (m)

11.55 (±0.35)

4.66 (±0.39)

6.65 (±0.47

Rotational behavior

Contralateral rotations

4.25 (±0.55)

3.58 (±0.42)

2.75 (±0.28)

Ipsilateral rotations

3.17 (±0.41)

3.08 (±0.4)

3.08 (±0.48)

Complex behavior

Time spent rearing (s)

51.33 (±2.39)

59.58 (±1.65)

69.58 (±1.72)

Time spent performing fine motor activity (s)

73.42 (±1.73)

50.50 (±3.61)

73.08 (±2.83)

B

V + D

Baseline

-CNO

+CNO

Principally motor behavior

Ambulation count (N)

9.25 (±0.59)

8.83 (±0.59)

12.83 (±0.76)

Average speed (m/s)

0.46 (±0.04)

0.47 (±0.03)

0.48 (±0.02)

Maximum speed (m/s)

0.72 (±0.3)

0.73 (±0.02)

0.72 (±0.03)

Time spent mobile (s)

213.40 (±4.5)

211.86 (±3.44)

218.48 (±3.36)

Distance covered (m)

10.26 (±0.39)

10.17 (±0.32)

11.57 (±0.57)

Rotational behavior

Contralateral rotations

3.50 (±0.39)

1.67 (±0.31)

4.42 (±0.31)

Ipsilateral rotations

3.25 (±0.41)

3.00 (±0.46)

3.25 (±0.46)

Complex behavior

Time spent rearing (s)

53.67 (±1.67)

54.33 (±3.0)

73.25 (±1.58)

Time spent performing fine motor activity (s)

75.58 (±2.14)

76.25 (2.48)

78.67 (±2.61)

C

L + CV

Baseline

-CNO

+CNO

Principally motor behavior

Ambulation count (N)

10.58 (±0.74)

4.83 (±0.39)

4.92 (±0.38)

Average speed (m/s)

0.51 (±0.04)

0.28 (±0.02)

0.27 (±0.03)

Maximum speed (m/s)

0.62 (±0.02)

0.45 (±0.02)

0.43 (±0.03)

Time spent mobile (s)

209.30 (±5.40)

191.70 (±6.06)

190.90 (±5.74)

Distance covered (m)

11.01 (±0.53)

5.12 (±0.53)

5.05 (±0.51)

Rotational behavior

Contralateral rotations

4.17 (±0.58)

1.58 (±0.42)

1.50 (±0.40)

Ipsilateral rotations

3.00 (±0.44)

3.25 (±0.39)

3.33 (±0.40)

Complex behavior

Time spent rearing (s)

48.17 (±1.89)

46.42 (±2.08)

45.42 (±1.97)

Time spent performing fine motor activity (s)

69.00 (±2.48)

47.67 (±4.39)

43.83 (±5.14)

D

V + CV

Baseline

-CNO

+CNO

Principally motor behavior

Ambulation count (N)

9.67 (±0.66)

9.83 (±0.63)

10.33 (±0.41)

Average speed (m/s)

0.52 (±0.04)

0.52 (±0.02)

0.52 (±0.02)

Maximum speed (m/s)

0.69 (±0.04)

1.15 (±0.43)

0.71 (±0.03)

Time spent mobile (s)

216.17 (±4.31)

217.15 (±3.77)

217.03 (±3.23)

Distance covered (m)

10.99 (±0.52)

11.07 (±0,43)

11.28 (±0.43)

Rotational behavior

Contralateral rotations

3.50 (±0.59)

3.75 (±0.45)

3.33 (±0.54)

Ipsilateral rotations

2.83 (±0.47)

3.00 (±0.44)

3.00 (±0.33)

Complex behavior

Time spent rearing (s)

50.83 (±2.09)

48.42 (±1.93)

49.25 (±2.08)

Time spent performing fine motor activity (s)

77.42 (±1.69)

78.33 (±1.61)

74.83 (±2.29)