Fig. 4
Effect of the NMDA receptor antagonist CPP on dendritic simplification. a Total path length and number of branching points of CA1 and CA3 neurons in the presence of the NMDAR antagonist CPP. Schematic representation of the time line of the respective experiment is shown on top. CPP reduces simplification in CA1 neurons. b Sholl analysis of basal and apical parts of the dendritic tree in CA1 neurons after CPP treatment. CPP completely abolishes simplification of APPSDL transgenic cultures in the basal part and reduces simplification in the apical part of the dendritic tree. (+) indicates significant increase, (#) significant decrease compared to the respective condition without the drug. Statistical evaluation was performed using one way ANOVA with post hoc Fisher’s LSD test for multiple comparisons (a) and Student’s t test for comparison of the two genotypes (b). Values are shown as mean and s.e.m. *(#)(+), p < 0.05. See Table 1 for details on the statistics