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Table 2 Effect of drug treatment on dendritic tau levels. Dendritic tau levels in 2nd or 3rd order of CA1 neurons expressing the respective construct were determined as described in “Methods”. For every neuron, 3–4 measurements were performed and averaged. Statistical evaluation was performed using two-tailed, unpaired Student’s t test for untreated cultures, and one way ANOVA with post hoc Fisher’s LSD test for multiple comparisons of drug treatments or different tau constructs. Note that alpha levels of ANOVA did not reach significance (p≤0.05) for any condition

From: Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

Construct Condition Region Genotype Mice (n) Cells (n) Mean ± s.e.m (based on cell number) of normalized intensity values Student’s t test   
p values (B6 vs. APP)
EGFP-htau untreated CA1 B6 3 5 1.061±0.099 p = 0.6210
EGFP-htau untreated CA1 APPSDL 5 5 1.111±0.120
Construct Condition Region Genotype Mice (n) Cells (n) Mean ± s.e.m (based on cell number) of normalized intensity values One way ANOVA (together with EGFP-htau untreated, both genotypes) p values (B6 vs. APP) p values (vs. untreated same genotype)
EGFP-htau DAPT CA1 B6 3 6 0.827±0.066 F (3,17) = 2.183 ; p = 0.1275 p = 0.0273 p = 0.2007
EGFP-htau DAPT CA1 APPSDL 4 5 1.197±0.154 p = 0.5981
EGFP-htau EpoD CA1 B6 4 5 1.119±0.138 F (3,16) = 0.2108 ; p = 0.8874 p = 0.8533 p = 0.5763
EGFP-htau EpoD CA1 APPSDL 5 5 1.148±0.066 p = 0.8135
EGFP-htau CPP CA1 B6 5 5 0.945±0.176 F (3,16) = 1.334 ; p = 0.2984 p = 0.3752 p = 0.6129
EGFP-htau CPP CA1 APPSDL 4 5 0.793±0.019 p = 0.0745
EGFP-Ala htau untreated CA1 B6 5 5 1.083±0.135 F (3,16) = 0.6240 ; p = 0.6098 p = 0.2952 p = 0.7390
EGFP-Ala htau untreated CA1 APPSDL 5 5 0.917±0.068 p = 0.2240
EGFP-PHP htau untreated CA1 B6 3 5 1.174±0.064 F (3,16) = 0.5229 ; p = 0.6727 p = 0.9881 p = 0.2937
EGFP-PHP htau untreated CA1 APPSDL 3 5 1.172±0.080 p = 0.6495