Skip to main content

Table 1 Proteins identified in column-binding fractions (selection)

From: Depletion of highly abundant proteins from human cerebrospinal fluid: a cautionary note

Protein

Accession

R

Reference

Cibacron Blue/Protein A – based depletion

   

 Junction plakoglobin

sp|P14923

>50

[4]

 Complement component C7

sp|P10643

>50

[7]

 Complement C5

sp|P01031

>50

[7]

 Plasminogen

sp|P00747

>50

[8]

 Colony-stimulating factor 1 receptor

tr|E9PEK4

>50

[5]

 Ectonucleotide pyrophosphatase/phosphodiesterase 2

tr|E7EUF1

>50

[7]

 Alpha-2-macroglobulin

sp|P01023

>50

[6]

 Coagulation factor V

sp|P12259

>50

[7]

 Complement factor B

tr|B4E1Z4

>50

[6]

 Complement C1r subcomponent

sp|P00736

>50

[7]

 Gelsolin

sp|P06396

>50

[6]

 Isoform 2 of amyloid-like protein 1

sp|P51693-2

>50

[6]

 Fibulin-1

sp|P23142

>50

[7]

 Complement C2

sp|P06681

>50

[6]

 Complement factor H

sp|P08603

>50

[9]

 Neurexin-2-alpha

sp|Q9P2S2

>50

[8]

 Complement C3

sp|P01024

>50

[8]

Antibody/Protein G – based depletion

   

 Desmoglein-1

sp|Q02413

>50

[8]

 Calmodulin-like protein 5

sp|Q9NZT1

50 > R > 20

[8]

 Collagen alpha-1(I) chain

sp|P02452

20 > R > 2

[8]

 Collagen, alpha-2(I) chain

tr|F5H299

20 > R > 2

[6]

 Complement factor H

sp|P08603

2 > R > 0.5

[9]

 Plasminogen

sp|P00747

2 > R > 0.5

[8]

 Alpha-1-antitrypsin

sp|P01009

2 > R > 0.5

[9]

 Isoform 2 of calsyntenin-1

sp|O94985-2

2 > R > 0.5

[9]

  1. Accession, accession number in SwissProt (sp)/Tremble (tr) data base; R, MS signal intensity ratio Icolumn-bound/Idepleted; Ref., reference suggesting eligibility as a biomarker; complete lists of identified proteins available as additional files (Additional files 3 and 4: Tables S1 and S2)