Fig. 3
From: Analysis of in vivo turnover of tau in a mouse model of tauopathy
Turnover of intracellular insoluble tau in pro-aggregant mice. a Doxycycline specifically reduced human tau in FA fractions of pro-aggregant mice. Human (black bars) and murine tau levels (white bars) in detergent insoluble fractions of pro-aggregant mice following doxycycline treatment were measured. (n = 4 for day 10, n = 5 forday 4 and day 18, n = 7 for day 8, n = 12 for day 0.). b Insoluble tau showed slower turnover than soluble tau in brain. Semi-log plot of soluble (black circles) and detergent insoluble human (white triangles) tau (Log % human tau) over time in pro-aggregant