Fig. 6
From: SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation
Aggregated SOD1 induces membrane ruffling in iPSC derived human motor neurons. Field emission SEM of motor neurons treated with SOD1 aggregates, and PBS or PMA controls. The area in the dashed box is enlarged in the bottom panels. Increases in membrane perturbations can be observed, such as ruffles and blebs (white arrow heads). Bars represent 20 μm in top row and 10 μm in the bottom row. Data shown is from experiments performed on cells derived from one fibroblast line and represents experiments performed on cells from 2 individuals