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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway

Fig. 4

Statin activates autophagy via AMPK-mTOR signaling pathway in astrocytes. a Inhibition of statin-mediated autophagy activation and IDE secretion by treatment with AMPK inhibitor (Compound C; CC). b Quantitative analysis of Fig. 4a (N = 3 experiments). * p < 0.05, ** p < 0.01 vs. vehicle-treated cells; # p < 0.05, ## p < 0.01 vs. cells treated with simvastatin. c Inhibition of statin-mediated autophagy activation by treatment with compound C. Anti-LC3 antibody was used to detect autophagy. Scale bar represents 6 μm. Lower panels show figures under higher magnification. Scale bar represents 2 μm. d The effect of statins on regulation of MMP-9 and NEP levels. e Quantitative analysis of Fig. 4d (N = 3 experiments)

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