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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay

Fig. 7

Correlation analysis of multiplexed potential markers with diagnostic ELISA data of the currently used clinical markers. a i-iii show markers transthyretin, IGF2 and GM2 activator protein in the AD group which correlate significantly with Aβ1-42 levels (measured by ELISA) in the AD group. There were no correlations observed for any of the markers in the LBD and control groups. b i-ii show markers transthyretin and IGF2 which correlate significantly with p-tau (ELISA data) only in the AD group. iii-v show markers cystatin C, ubiquitin and osteopontin which correlate with p-tau in all groups indicating that their expression is likely to reflect p-tau expression. vi and vii show markers ApoE and malate dehydrogenase which correlate with p-tau in both AD and LBD disease groups. viii and ix also show correlation of ApoE and malate dehydrogenase with total tau (h-tau) expression

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Molecular Neurodegeneration

ISSN: 1750-1326