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Table 2 Linear regression modelsa predicting global or single-domain cognitive function

From: Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Model no. and terms Global cognition Episodic memory Semantic memory Working memory Perceptual speed Visuospatial ability
(n = 302) (n = 302) (n = 296) (n = 301) (n = 293) (n = 289)
r 2 or βb p-value r 2 or β p-value r 2 or β p-value r 2 or β p-value r 2 or β p-value r 2 or β p-value
Model 1 0.328   0.394   0.208   0.174   0.189   0.121  
AD pathology −0.872 <0.001 −1.091 <0.001 −0.713 <0.001 −0.634 <0.001 −0.477 <0.001 −0.362 0.014
Macroinfarcts −0.283 0.016 −0.253 0.039 −0.366 0.011 −0.470 0.001 −0.052 0.681 −0.065 0.657
Lewy bodies −0.184 0.193 −0.111 0.452 −0.027 0.875 −0.102 0.533 −0.027 0.857 −0.112 0.518
Hipp sclerosis −0.660 0.001 −1.034 <0.001 −0.662 0.005 −0.143 0.529 −0.687 0.001 −0.315 0.198
Model 2 0.345   0.406   0.226   0.193   0.193   0.123  
AD pathology −0.793 <0.001 −1.018 <0.001 −0.628 <0.001 −0.549 <0.001 −0.434 0.001 −0.323 0.032
Macroinfarcts −0.269 0.021 −0.240 0.048 −0.347 0.014 −0.455 0.001 −0.043 0.731 −0.058 0.693
Lewy bodies −0.141 0.314 −0.071 0.630 0.021 0.900 −0.055 0.735 −0.004 0.981 −0.088 0.611
Hipp sclerosis −0.658 0.001 −1.032 <0.001 −0.665 0.005 −0.141 0.530 −0.686 0.001 −0.317 0.196
M18Lc 0.0010 0.003 0.0009 0.009 0.0012 0.006 0.0011 0.006 0.0005 0.141 0.0005 0.226
Model 3 0.328   0.392   0.209   0.177   0.188   0.120  
AD pathology −0.865 <0.001 −1.090 <0.001 −0.707 <0.001 −0.624 <0.001 −0.470 <0.001 −0.357 0.016
Macroinfarcts −0.290 0.014 −0.255 0.038 −0.372 0.010 −0.483 <0.001 −0.057 0.650 −0.071 0.629
Lewy bodies −0.175 0.217 −0.108 0.464 −0.011 0.947 −0.086 0.598 −0.018 0.907 −0.100 0.566
Hipp sclerosis −0.670 0.001 −1.037 <0.001 −0.676 0.005 −0.160 0.480 −0.696 0.001 −0.325 0.184
M18Sc 0.0016 0.331 0.0004 0.794 0.0024 0.247 0.0027 0.150 0.0015 0.389 0.0018 0.383
Model 4 0.343   0.405   0.224   0.191   0.190   0.120  
AD pathology −0.793 0.001 −1.014 <0.001 −0.629 <0.001 −0.551 <0.001 −0.436 0.001 −0.626 0.021
Macroinfarcts −0.267 0.022 −0.232 0.057 −0.348 0.014 −0.460 0.001 −0.047 0.714 −0.062 0.673
Lewy bodies −0.141 0.313 −0.074 0.614 0.022 0.896 −0.053 0.745 −0.002 0.990 −0.085 0.625
Hipp sclerosis −0.657 0.001 −1.023 <0.001 −0.667 0.005 −0.146 0.515 −0.690 0.001 −0.321 0.189
M18Lc 0.0010 0.006 0.0011 0.006 0.0011 0.013 0.0010 0.017 0.0005 0.217 0.0004 0.343
M18Sc −0.0003 0.877 −0.0015 0.419 0.0003 0.890 0.0009 0.669 0.0006 0.741 0.0010 0.658
  1. Abbreviations: AD Alzheimer’s disease Hipp, hippocampal; M18L/S, Munc18-1 long/short splice variant
  2. aAll models included terms (not shown) for age, sex, education, microinfarcts, arteriolosclerosis, and atherosclerosis
  3. bValues are whole model adjusted r-squared, or individual β-coefficients for each term
  4. cStandardized M18L/S values (z-scores) were used