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Table 3 Logistic regression modelsa predicting likelihood of clinical dementia per unit of term

From: Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Model terms Model 1 Model 2 Model 3 Model 4
Odds ratio 95 % CI p-value Odds ratio 95 % CI p-value Odds ratio 95 % CI p-value Odds ratio 95 % CI p-value
AD pathology 3.15 1.80–5.73 <0.001 2.84 1.60–5.22 <0.001 3.16 1.81–5.75 <0.001 2.83 1.59–5.21 <0.001
Macroinfarcts 2.16 1.20–3.94 0.010 2.06 1.14–3.79 0.017 2.20 1.22–4.02 0.009 2.05 1.13–3.78 0.018
Microinfarcts 0.73 0.39–1.36 0.326 0.77 0.41–1.43 0.412 0.75 0.40–1.40 0.370 0.77 0.41–1.43 0.409
Arteriolosclerosis 1.30 0.95–1.78 0.098 1.34 0.98–1.84 0.068 1.32 0.97–1.82 0.078 1.33 0.98–1.84 0.071
Atherosclerosis 1.36 1.02–1.82 0.035 1.36 1.02–1.84 0.038 1.34 1.00–1.80 0.046 1.36 1.02–1.84 0.038
Lewy bodies 4.92 1.79–15.40 0.002 4.63 1.67–14.70 0.003 4.93 1.79–15.51 0.002 4.62 1.66–14.66 0.003
Hipp sclerosis 4.39 1.72–12.16 0.002 4.41 1.70–12.39 0.002 4.59 1.78–12.80 0.001 4.38 1.68–12.34 0.002
M18Lb     0.68 0.50–0.90 0.008     0.67 0.47–0.93 0.018
M18Sb        0.84 0.64–1.10 0.208 1.03 0.75–1.43 0.871
  1. Abbreviations: AD Alzheimer’s disease, CI confidence interval Hipp, hippocampal, M18L/S Munc18-1 long/short splice variant
  2. aAll models were controlled for age, sex and education
  3. bStandardized M18L/S values (z-scores) were used