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Table 3 Logistic regression modelsa predicting likelihood of clinical dementia per unit of term

From: Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

Model terms

Model 1

Model 2

Model 3

Model 4

Odds ratio

95 % CI

p-value

Odds ratio

95 % CI

p-value

Odds ratio

95 % CI

p-value

Odds ratio

95 % CI

p-value

AD pathology

3.15

1.80–5.73

<0.001

2.84

1.60–5.22

<0.001

3.16

1.81–5.75

<0.001

2.83

1.59–5.21

<0.001

Macroinfarcts

2.16

1.20–3.94

0.010

2.06

1.14–3.79

0.017

2.20

1.22–4.02

0.009

2.05

1.13–3.78

0.018

Microinfarcts

0.73

0.39–1.36

0.326

0.77

0.41–1.43

0.412

0.75

0.40–1.40

0.370

0.77

0.41–1.43

0.409

Arteriolosclerosis

1.30

0.95–1.78

0.098

1.34

0.98–1.84

0.068

1.32

0.97–1.82

0.078

1.33

0.98–1.84

0.071

Atherosclerosis

1.36

1.02–1.82

0.035

1.36

1.02–1.84

0.038

1.34

1.00–1.80

0.046

1.36

1.02–1.84

0.038

Lewy bodies

4.92

1.79–15.40

0.002

4.63

1.67–14.70

0.003

4.93

1.79–15.51

0.002

4.62

1.66–14.66

0.003

Hipp sclerosis

4.39

1.72–12.16

0.002

4.41

1.70–12.39

0.002

4.59

1.78–12.80

0.001

4.38

1.68–12.34

0.002

M18Lb

   

0.68

0.50–0.90

0.008

   

0.67

0.47–0.93

0.018

M18Sb

      

0.84

0.64–1.10

0.208

1.03

0.75–1.43

0.871

  1. Abbreviations: AD Alzheimer’s disease, CI confidence interval Hipp, hippocampal, M18L/S Munc18-1 long/short splice variant
  2. aAll models were controlled for age, sex and education
  3. bStandardized M18L/S values (z-scores) were used