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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model

Fig. 3

mHTT-ΔN17-exon1 transgenic fish exhibit reduced brain weight. a Body length is not statistically different between HTT-ΔN17-exon1 and mHTT-ΔN17-exon1 without (−HS) or with heat shock (+HS) (n = 8 for each condition). b Body weight is not statistically different between HTT-ΔN17-exon1 and mHTT-ΔN17-exon1 with or without heat shock (n = 8 for each condition). c The brain weight of mHTT-ΔN17-exon1 after heat shock induction of the HTT transgene is significantly less than either non-heat shocked mHTT-ΔN17-exon1 fish or heat shocked HTT-ΔN17-exon1 fish (n = 8 for each condition). (*) p < 0.05 by Student’s t-test. Error bars are SEM

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