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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model

Fig. 6

Behavioral characterization of elavl3:cre/mHTT-ΔN17-exon1. Field potential recordings were made from freely behaving elavl3:cre/HTT-ΔN17 fish (n = 6) and elavl3:cre/mHTT-ΔN17-exon1 (n = 6) fish exhibiting Stage 1 behaviors. Field potentials represent the electrical muscle activity of a given freely behaving animal as measured by recording electrodes placed in the chamber during movements. Each fish was allowed to acclimate to the recording chamber for 5 min and then recorded for 5 min. a Representative field potential recordings from an elavl3:cre/HTT-ΔN17-exon1 fish (top) and an elavl3:cre/mHTT-ΔN17-exon1 fish (bottom). Brackets define of swimming activity. Note the short, distinct swimming activity of the elavl3:cre/HTT-ΔN17-exon1 fish versus the sustained activity of the elavl3:cre/mHTT-ΔN17-exon1 fish. b Average movement frequency as calculated by counting each distinct, non-overlapping movement waveform over time. elavl3:cre/mHTT-ΔN17-exon1 fish move significantly less often than elavl3:cre/HTT-ΔN17-exon1 fish. c elavl3:cre/mHTT-ΔN17-exon1 fish display extended periods of activity as compared to elavl3:cre/HTT-ΔN17-exon1 fish. d Total time moving is not significantly different between elavl3:cre/HTT-ΔN17-exon1 and elavl3:cre/mHTT-ΔN17-exon1 fish. (*) p < 0.05 by Student’s t-test. Error bars are SEM

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