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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson’s disease

Fig. 4

Effect of SZV compounds on endogenous dopamine content in the striatum (a, c, d); on the survival of mice (b); on endogenous dopamine metabolite (DOPAC, HVA) levels (e, f); on the basal locomotor activity (g) and on motor coordination (h) after in vivo MPTP treatment. a Effect of test compounds and rasagiline (10 mg/kg i.p. each) on endogenous dopamine level in the striatum; b on the survival of the animals. Survival is expressed as percentage of the initial number of animals. c Dose-dependent effect of SZV558 (0.1-10 mg/kg i.p.) on endogenous dopamine content in the striatum. d Effect of SZV558 and rasagiline (20 mg/kg per os each) on endogenous dopamine content in the striatum. a, c, d Dopamine content is expressed as pmol/mg protein. e, f Effect of SZV compounds (10 mg/kg i.p.) on endogenous dopamine metabolite (DOPAC, HVA) levels. Metabolite levels are expressed as pmol/mg protein. g Effect of SZV compounds (10 mg/kg i.p.) on the basal locomotor activity, measured in the open field test. Locomotion is expressed as the distance traveled during the whole 30 min test period. a-g Symbols represent significant changes from saline treated (++ P < 0.01, +++ P < 0.001), MPTP treated (**P < 0.01, ***P < 0.001) and rasagiline (10 mg/kg) treated (## P < 0.05, ### P < 0.001) animals, respectively. Statistical analysis: one-way ANOVA followed by the Tukey test, except b: log rank test. Number of independent experiments: 5-12/group. h Effect of SZV compounds (10 mg/kg i.p.) on the motor performance measured on the rotarod test. The time elapsed until the falling of the mice was expressed in sec. Symbols represent significant changes from respective pretreatment values (**P < 0.01). Statistical analysis: one-way ANOVA followed by the Dunnett test

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