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Table 2 Analysis of APOE genotypes and allele frequency in Chinese population

From: A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism

Cohort No. APOE genotypes (No.) Accuracy (%) Alleles (%)
   ε2/ε2 ε2/ε3 ε2/ε4 ε3/ε3 ε3/ε4 ε4/ε4   ε2 ε3 ε4
Zhongshan 399 2 60 6 278 51 2 100 8.77 83.58 7.65
Fujian 390 2 50 5 271 60 2 100 7.56 83.59 8.85
Huadong 369 3 43 5 265 52 1 100 7.32 84.69 7.99
Total 1158 7 153 16 814 163 5 100 7.90 83.94 8.16
  1. Genomic DNA was extracted from peripheral blood samples obtained from three hospitals (399 samples from Zhongshan Hospital Affiliated to Xiamen University, 390 samples from Fujian Medical University Union Hospital, and 369 samples from Huadong Hospital Affiliated to Fudan University). The APOE genotypes and allele frequency were analyzed by both Real Time PCR and DNA sequencing. The 100 % accuracy was defined when APOE genotyping using the Real Time PCR assay showed 100 % concordance with DNA sequencing results