From: Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease
Subject details | Controls (n = 22) | AD patients (n = 37) | p value |
---|---|---|---|
Gender (F/M), no (%) | 10(45)/12(55) | 19(53)/18(47) | 0.6 |
Age, years (mean ± SD) | 69.2 ± 8.0 | 70.51 ± 7.5 | 0.54 |
MMSE score (median IQR) | 29.00(26.50-29.00) | 22.00(18.00-25.00 | <0.0001 |
APOE ε4 positive (%) | 33 % | 67 % | 0.0002 |
Plasma CRP (mg/L), median (IQR) | 2.095 (0.8425 – 4.7535) n = 16 | 1.020 (0.6500 – 1.295) n = 25 | 0.0543 |
CSF Biomarkers | |||
Aβ1-42 (pg/ml), median (IQR) | 978.5(821.8-1045) | 367.0(301.0-433.0) | <0.0001 |
T-tau (pg/ml), median (IQR) | 239.5(196.3-279.0) | 596.0(455.0-858.5) | <0.0001 |
P-tau181 (pg/ml), median (IQR) | 45.0(36.8-58.3) | 95.0(75.0-111.5) | <0.0001 |
T-tau/Aβ1-42 ratio, median (IQR) | 0.25(0.19-0.33) | 1.56(1.24-2.55) | <0.0001 |
sTREM2 (pg/ml), median (IQR) | 195.6(131.0-240.7) | 231.2(172.5-305.4) | 0.0457 |